Summary of Cancer Cachexia Improvement Agent and Cancer Cachexia Improvement Method
This invention pertains to a cancer cachexia improvement agent and a method for improving cancer cachexia
Cancer cachexia, commonly referred to as Cancer Anorexia-Cachexia Syndrome (CACS), is a multifactorial syndrome in the advanced stages of cancer. The symptoms of cancer cachexia primarily include weight loss, accompanied by conditions such as malnutrition and anemia. As a method to treat cachexia in the terminal stages of cancer, the aim is to improve or alleviate these symptoms, thus enhancing the Quality of Life (QOL) and Activities of Daily Living (ADL) during the remaining lifespan, even if the overall survival period cannot be extended.
The challenge that the present invention aims to address is to provide a novel cancer cachexia improvement agent. The inventors of the present invention have discovered that microvesicles, such as exosomes derived from the culture supernatant of dental pulp-derived stem cells or from the culture supernatant itself, can alleviate various symptoms of cachexia in a cancer cachexia model mouse.
